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KMID : 0644320020080010079
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Journal of Korean Oriental Oncology
2002 Volume.8 No. 1 p.79 ~ p.92
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Angiogenic Inhibition Effects of Several Herbs Supplementing Qi and Blood
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Lee Jin-Wha
Kim Han-Young
Kang Hee
Yu Young-Beob
Shim Bum-Sang
Ahn Kyoo-Seok
Choi Seung-Hun
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Abstract
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Two of the essential processes required for metastasis are neoangiogenesis and tumor cell invasion of basement membranes (BM) and extracellular matrix (ECM). Recently, data showed that herbs removing blood stasis has an anti-angiogenic effects. Tonifying vital Qi and eliminating pathogenic factor was a basic modality in Oriental oncology. In this study, we investigated several Qi and Blood tonics for potent angiogenic inhibitors. Methanol extracts of samples inhibited the proliferation of ECV-304 at the concentration of 100ug/ml. Zizyphi Fructus, Glycyrrhizae Radix, Angelicae Gigantis Radix decreased the gelatinolytic activity of MMP-9 from ECV-304, at the concentration of 100ug/ml in gelatin zymography. In in vitro invasion assay, herbs inhibited the invasion activity of ECV-304 by 53% of control (Ginseng Radix), 39% (Zizyphi Fructus), 36% (Angelicae Gigantis Radix), 25% (Glycyrrhizae Radix). Ginseng Radix inhibited the capillary-like tube formation of ECV-3O4 at the concentration of 160ug/ml, Angelicae Gigantis Radix and Paeoniae Radix Alba inhibited at the concentration of 320ug/ml. These results indicated that Ginseng Radix, Glycyrrhizae Radix, and Angelicae Gigantis Radix could be considered as potent angiogenic inhibitiors.
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KEYWORD
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anti-angiogenesis, Ginseng Radix, GlycyrrhizaeRadix, AngelicaeGigantisRadix
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